ArticleAmerican journal of translational research2026
Amlodipine Besylate-Folic Acid demonstrates superior efficacy to Enalapril Maleate-Folic Acid in treating H-type hypertension.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis retrospective research was designed to compare the treatment outcomes of H-type hypertension (HTH) patients treated with Amlodipine Besylate-Folic Acid Tablets (Amlo-FA) vs. Enalapril Maleate-Folic Acid Tablets (Ena-FA).
methodsThis investigation comprised 155 HTH cases. The control group was treated with the Ena-FA regimen, while the observation group received Amlo-FA therapy. Patients' clinical data were comparatively analyzed.
resultsCompared to controls, the observation group demonstrated superior overall treatment effectiveness (90.48% vs. 71.83%, P=0.003). Following treatment, systolic blood pressure (SBP; (129.86±6.24) mmHg vs. (139.66±8.04) mmHg, P<0.001), diastolic blood pressure (DBP; (80.26±7.46) mmHg vs. (89.00±9.68) mmHg, P<0.001), homocysteine (Hcy; (13.06±3.18) μmol/L vs. (19.39±3.37) μmol/L, P<0.001), carotid intima-media thickness (CIMT; (1.11±0.28) mm vs. (1.29±0.27) mm, P<0.001), fasting blood glucose (FPG; (5.74±1.68) mmol/L vs. (6.40±2.02) mmol/L, P=0.028), glycosylated hemoglobin (HbA1c; (5.85±1.85)% vs. (6.93±1.90)%, P<0.001), urinary albumin-to-creatinine ratio (UACR; (53.64±15.44) mg/L vs. (74.17±16.96) mg/L, P<0.001), total cholesterol (TC; (4.92±1.61) mmol/L vs. (6.42±1.63) mmol/L, P<0.001), TG (triglycerides; (1.66±0.72) mmol/L vs. (2.44±0.68) mmol/L, P<0.001), and low-density lipoprotein cholesterol (LDL-C; (2.35±0.70) mmol/L vs. (2.99±0.84) mmol/L, P<0.001) were markedly reduced in the observation cohort relative to the control group outcomes. Conversely, high-density lipoprotein cholesterol (HDL-C; (1.78±0.69) mmol/L vs. (1.47±0.50) mmol/L, P=0.002), Medication Adherence Self-Efficacy Scale (MASES; (89.31±8.87) score vs. (79.70±7.61) score, P<0.001), and the 8-item Morisky Medication Adherence Scale (MMAS-8; 5.00 (3.00, 6.00) score vs. 6.00 (4.00, 7.00) score, P<0.001) scores showed a significant increase under the same comparisons. The overall side effect profile was significantly more favorable in the observation group (5.95% vs. 16.90%, P=0.030). No significant inter-group differences were observed in the incidence of various individual and total adverse cardiovascular and cerebrovascular events (4.76% vs. 12.68%, P>0.05). Finally, comorbid diabetes (B=1.447, OR=4.250, P=0.010) and treatment methods (B=-1.196, OR=0.303, P=0.013) were factors independently influencing patients' curative effects.
conclusionAmlo-FA is effective in treating HTH.
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