Evidence map›Paper›PMID 41868834›Full record

ArticleFrontiers in psychiatry2026

BDNF genetic variants modulate the impact of childhood trauma on symptom dimensions in first-episode schizophrenia.

Junjiao Ping, Yong Wu, Jiali Luo, Ying Zhang, Tingyun Jiang, Yonghui Dang

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Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Junjiao PingCollege of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shanxi, China.
Yong WuDepartment of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China.
Jiali LuoDepartment of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China.
Ying ZhangDepartment of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China.
Tingyun JiangDepartment of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China.
Yonghui DangCollege of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gene-environment interactions play a critical role in shaping phenotypic heterogeneity in complex psychiatric disorders. Brain-derived neurotrophic factor (BDNF) is a key genetic regulator of stress-sensitive neuroplasticity. Yet, how Methods: We conducted a case-control study including 93 patients with first-episode schizophrenia (SZ) and 64 healthy controls. Childhood trauma exposure was assessed using the Childhood Trauma Questionnaire (CTQ), and symptom dimensions were evaluated with the Positive and Negative Syndrome Scale (PANSS). Three Results: Patients with SZ exhibited significantly higher CTQ scores across all trauma subtypes compared with controls (all Conclusion: These findings demonstrate that

Indexed as

BDNFchildhood traumaclinical symptomsgene polymorphismschizophrenia

Identifiers

PMID41868834
PMCPMC12999866

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