Evidence map›Paper›PMID 41868814›Full record

ArticlePleura and peritoneum2026

Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.

Vinita Popat, Paul H Frankel, Nora H Ruel, Susan E Yost, Sue Chang, Edward Wang, Jeannine Villella, Jill Whyte, Richard L Whelan, Melissa Eng and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pleura and peritoneum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04329494 (Safety and Efficacy of Pressurized Intraperitoneal Aerosolized Chemotherapy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04329494 phase1recruitingnot on this map

Safety and Efficacy of Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Ovarian, Uterine, Appendiceal, Colorectal, and Gastric Cancer Patients With Peritoneal Carcinomatosis (PC)

TypeinterventionalSponsorCity of Hope Medical CenterRan2020 to 2028Enrolled49ConditionsClinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8, Clinical Stage IVB Gastric Cancer AJCC v8, Malignant Uterine NeoplasmArmsBiopsy, Cisplatin, Doxorubicin, Fluorouracil, Intraperitoneal Chemotherapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Vinita PopatDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Paul H FrankelDepartment of Computation and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA, USA.
Nora H RuelDepartment of Computation and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA, USA.
Susan E YostDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Sue ChangDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
Edward WangDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Jeannine VillellaDepartment of Obstetrics and Gynecology, Northwell Health, New York, NY, USA.
Jill WhyteDepartment of Obstetrics and Gynecology, Northwell Health, New York, NY, USA.
Richard L WhelanDepartment of Surgery, Northwell Health, New York, NY, USA.
Melissa EngDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Raechelle TinsleyDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Tim SynoldDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Ernest HanDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Mihae SongDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Joshua CohenDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Mustafa RaoofDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Thanh Hue DellingerDepartment of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID https://orcid.org/0000-0003-1855-1989

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

Objectives: Ovarian cancer (OC) often presents with peritoneal metastases (PM) which contribute significantly to morbidity and treatment resistance. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) has emerged as a promising modality for locoregional drug delivery in peritoneal surface malignancies. Historically, combined intraperitoneal (IP) and intravenous (IV) cisplatin and paclitaxel regimens have demonstrated activity in first-line OC treatment. PIPAC nab-paclitaxel and cisplatin with systemic nab-paclitaxel holds promise as a safe and effective therapy, but has not been explored in OC. Methods: This ongoing, dose de-escalation, single-arm phase I study evaluates triplet bidirectional chemotherapy with a safety lead-in (NCT04329494). The study evaluates the safety and tolerability of a 28-day cycle of Day 1 PIPAC nab-paclitaxel 90 mg/m Results: Enrollment is ongoing at U.S. academic centers. The primary endpoints are dose-limiting toxicities and adverse events. Secondary endpoints include radiographic (RECIST v1.1), histologic, and surgical response, progression-free and overall survival, and post-operative complications. Conclusions: This study investigates the safety, feasibility, and preliminary activity of the combination of PIPAC and systemic IV chemotherapy in recurrent OC patients to determine efficacy and safety for a future Phase II trial.

Indexed as

multimodal therapynab-paclitaxelovarian cancerphase I trialPIPAC

Identifiers

PMID41868814
PMCPMC13001819

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.