ArticlePeerJ2026
Restless legs syndrome and sleep quality in children with migraine and tension-type headache.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Headache disorders and sleep disturbances are common in children, with migraine and tension-type headache (TTH) being the most prevalent primary headache subtypes. Restless legs syndrome (RLS) is more frequently reported in children with migraine and may exacerbate sleep disturbances and related cognitive and quality-of-life impairments via shared neurobiological mechanisms; its prevalence across pediatric headache subtypes and its association with sleep quality remain insufficiently characterized. Therefore, this study aimed to assess the prevalence of RLS in children diagnosed with migraine or TTH and to examine its relationship with sleep quality. Methods: In this cross-sectional study, 148 children with primary headaches (99 migraine, 49 TTH) and 148 age- and sex-matched healthy controls were included. The diagnosis of RLS was established using the pediatric criteria of the International Restless Legs Syndrome Study Group. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Group comparisons were performed to evaluate differences in RLS prevalence among headache subtypes and controls using chi-square tests, while group comparisons of continuous variables were performed using nonparametric tests. Spearman correlation was used to assess the relationship between RLS and sleep quality. In addition, mediation analysis was conducted to explore the role of RLS presence in the association between migraine and sleep quality. Results: RLS was detected in 20.9% of participants with primary headaches and in 8.8% of healthy controls, with a statistically significant difference between the groups ( Conclusion: RLS was observed significantly more frequently among children with primary headaches, particularly migraine, and was significantly associated with poorer sleep quality. RLS may act as a contributing factor in the relationship between migraine and sleep impairment. These findings highlight the importance of evaluating RLS and sleep disturbances during the clinical assessment of pediatric patients with recurrent headache.
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