Evidence map›Paper›PMID 41868690›Full record

ArticlePain reports2026

Cuff algometry induces large yet variable conditioned pain modulation effects.

Joseph L Taylor, Timothy Lawn, Olivia S Kowalczyk, Thomas Graven-Nielsen, Matthew A Howard, Kirsty Bannister

Abstract read
In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph L TaylorWolfson Sensory Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-4331-2162
Timothy LawnDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-1643-5987
Olivia S KowalczykDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-6543-290X
Thomas Graven-NielsenCenter for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0000-0002-7787-4860
Matthew A HowardDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-9359-3057
Kirsty BannisterDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-3043-3574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Conditioned pain modulation (CPM) paradigms provide a proxy measure of activity in the descending pain modulatory system. Cuff-pressure algometry offers a standardised CPM assessment tool although comprehensive validation in large samples is lacking. Objective: To characterise cuff-pressure-algometry assessed CPM and its test-retest reliability in a large healthy control sample. Methods: Cuff-algometry CPM data from 324 healthy participants across 8 studies were pooled. Conditioned pain modulation magnitude was calculated as pain detection threshold (PDT) and pain tolerance threshold (PTT) changes, assessed on the dominant leg in the presence and absence of a painful "conditioning" cuff stimulus on the contralateral leg. Results: Conditioned pain modulation effects were robust for both changes in PDT and PTT ( Conclusion: Despite producing large group-level CPM effects,

Indexed as

Conditioned pain modulationCuff algometryModulationPainPain thresholdPain tolerancePsychophysicsReliabilityVariability

Identifiers

PMID41868690
PMCPMC13004212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.