Evidence map›Paper›PMID 41868675›Full record

ReviewAmerican journal of cancer research2026

Epigenetic modifications in ferroptosis regulation of breast cancer.

Lin Lin, Yunyang Wang, Wenzhe Si, Xujun Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lin LinDepartment of Laboratory Medicine, Peking University First Hospital Beijing, China.
Yunyang WangDepartment of Laboratory Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, National Health Commission, Peking University Third Hospital Beijing, China.
Wenzhe SiDepartment of Laboratory Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, National Health Commission, Peking University Third Hospital Beijing, China.
Xujun LiuDepartment of Laboratory Medicine, Peking University First Hospital Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most frequently diagnosed type of cancer worldwide and has become the primary cause of cancer deaths in women, presenting many difficulties for treatment due to its molecular heterogeneity, dynamic tumor microenvironment and frequent development of resistance to traditional drugs and targeted therapies. Ferroptosis is a type of genetically regulated, iron-dependent cell death that occurs due to the extensive accumulation of phospholipid hydroperoxides, and it has been identified as an essential tumor-suppressive mechanism with significant implications for the pathogenesis, progression and treatment response of BC. Recent evidence shows that epigenetic mechanisms, including DNA methylation, histone post-translational modifications, and non-coding RNA-mediated regulation (microRNA, long non-coding RNA, circular RNA), precisely control the core ferroptosis machinery system Xc

Indexed as

Breast cancerepigenetic modificationferroptosis

Identifiers

PMID41868675
PMCPMC13000150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.