Evidence map›Paper›PMID 41868661›Full record

ArticleAmerican journal of cancer research2026

MicroRNA-mediated MAPK signaling promotes isoliensinine-induced apoptosis in oral squamous cell carcinoma via the ROS-dependent mitochondrial pathway and G2 phase arrest.

Zi-Wei Cai, Wei Zhao, Yu-Ping Gong, Yi-Chuan Zhou, Shi-Qi Pu, Xiao-Yu Bai, Jia-Qi Li, Jia Chen, Yi-Yuan Bi, Yang Wan and 3 more

Abstract read
In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zi-Wei CaiSchool of Basic Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Wei ZhaoSchool of Basic Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Yu-Ping GongSchool of Bioscience and Technology, Chengdu Medical College Chengdu 610500, Sichuan, China.
Yi-Chuan ZhouSchool of Laboratory Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Shi-Qi PuSchool of Laboratory Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Xiao-Yu BaiSchool of Bioscience and Technology, Chengdu Medical College Chengdu 610500, Sichuan, China.
Jia-Qi LiSchool of Clinical Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Jia ChenSchool of Clinical Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Yi-Yuan BiSchool of Clinical Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Yang WanSchool of Basic Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Yu HeDepartment of Oncology, Nanbu People's Hospital Nanchong 637300, Sichuan, China.
Ping YangSchool of Basic Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.
Min-Hui LiSchool of Basic Medicine, Chengdu Medical College Chengdu 610500, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignancy. Isoliensinine, a bisbenzylisoquinoline alkaloid from

Indexed as

apoptosisIsoliensinineMAPK signaling pathwayMicroRNAoral squamous cell carcinomareactive oxygen species

Identifiers

PMID41868661
PMCPMC13000128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.