ArticleAmerican journal of cancer research2026
Prognostic value of systemic inflammatory and nutritional markers in patients with resectable colon cancer: a retrospective observational study.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Predictors of Metastatic Lymph Node Burden in Colorectal Cancer: A Negative Binomial Regression Analysis.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer remains a leading cause of global cancer morbidity. While pathological staging is a cornerstone of prognosis, host-related factors, including systemic inflammatory response and nutritional status, are increasingly recognized as critical determinants of outcomes.
methodsThis single-center retrospective study investigated the prognostic value of preoperative hematologic markers - neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, C-reactive protein-to-albumin ratio, prognostic nutritional index (PNI), and the Controlling Nutritional Status score - in 113 patients who underwent radical colectomy between December 2020 and June 2022. The primary and secondary endpoints were 3-year disease-free survival (DFS) and overall survival (OS), respectively.
resultsThe cohort demonstrated 3-year DFS and OS rates of 74.1% and 77.0%, respectively, and an overall recurrence rate of 23.9% within the follow-up period. Multivariate Cox analysis identified a high PNI (≥ 43.62) as an independent protective factor for 3-year DFS (hazard ratio [HR] = 0.057, 95% confidence interval [CI]: 0.016-0.125,
conclusionPreoperative PNI and PLR are readily accessible, independent prognostic biomarkers for patients with resectable colon cancer. They augment traditional Tumor, Node, Metastasis staging by reflecting the critical balance between pro-tumor inflammation and host immunonutritional status within the tumor microenvironment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.