ReviewBrain, behavior, & immunity - health2026
The relationship between the gut microbiota and neuropsychological development and behaviour during childhood and adolescence: a systematic review of epidemiological studies.
Review in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Mounting evidence suggests that early-life microbial colonization might shape cognitive development and behaviour. This systematic review summarizes current research on the relationship between the gut microbiota and neuropsychological development and behaviour in children and adolescents (0-18 years). Following PRISMA guidelines, we conducted a comprehensive search across MEDLINE, Scopus, and Web of Science, identifying 78 eligible studies covering both clinical neurodevelopmental disorders and general-population neuropsychological outcomes. We observed a high heterogeneity across studies regarding study design, statistical analyses and the consideration of confounding factors (e.g., diet, medication use), gut microbiota determinations and the assessment of neurobehavioural outcomes. Only 42% of studies used longitudinal designs, and confounding factors were frequently unaddressed. Microbiome alterations in autism spectrum disorder (n = 23 studies) included community structure shifts, elevated
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