ArticleFrontiers in neurology
Impact of blood pressure levels and variability after successful revascularization on the prognosis in ICAS-LVOS patients.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: Optimal blood pressure management after endovascular treatment (EVT) for intracranial atherosclerosis-related large vessel occlusion stroke (ICAS-LVOS) remains uncertain. This study evaluated the impact of systolic blood pressure (SBP) and blood pressure variability (BPV) on early outcomes following successful recanalization. Methods: We prospectively enrolled 110 ICAS-LVOS patients (Jan 2020-Dec 2024). Hourly SBP was recorded for 24 h post-EVT. BPV metrics included standard deviation (SD), coefficient of variation (CV), average real variability (ARV), and fluctuation frequency (|∆SBP| ≥ 10 mmHg). Outcomes included early favorable prognosis [National Institutes of Health Stroke Scale (NIHSS) ≤ 7], early neurological deterioration (ΔNIHSS ≥ + 2), and hemorrhagic transformation (HT). Results: 110 patients were recruited. Generalized estimating equation analyses demonstrated that higher hourly SBP levels and higher |∆SBP| showed an associated with a decreased likelihood of NIHSS ≤ 7 and an increased risk of ΔNIHSS ≥ + 2. Logistic regression confirmed that lower mean SBP ( Conclusion: Higher post-EVT SBP levels and greater SBP variability were associated with reduced early recovery and an increased risk of neurological deterioration in ICAS-LVOS. Blood pressure should be maintained at a relatively low, consistent level.
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