ArticleFrontiers in neurology
Combined value of triglyceride-glucose index and non-high-density lipoprotein cholesterol in predicting early cognitive impairment after acute ischemic stroke.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
Background: Acute ischemic stroke (AIS) represents a significant global cause of mortality and long-term disability. Cognitive impairment frequently occurs among AIS patients, adversely affecting their functional outcomes. Identifying modifiable risk factors linked to cognitive dysfunction after stroke is thus critical for effective prevention and targeted therapeutic interventions. Objective: This study explored the relationship between serum triglyceride-glucose (TyG) index and non-high-density lipoprotein cholesterol (non-HDL-C) levels and early cognitive impairment in AIS patients. Methods: The Neurology Department of Anhui Medical University's Fourth Affiliated Hospital recruited a total of 235 individuals diagnosed with AIS between September 2023 and January 2025. Patients served as a cognitive impairment group ( Results: The cognitive impairment group exhibited significantly elevated TyG index and non-HDL-C serum levels ( Conclusion: Elevated serum levels of TyG index and non-HDL-C independently predict early cognitive impairment in AIS patients, with their combination significantly improving predictive accuracy. These results suggest potential benefits from early metabolic interventions to enhance cognitive recovery post-stroke.
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