ArticleFrontiers in aging neuroscience2026
Association of gait, balance, and handgrip strength with cognitive performance in hospitalized older adults: a retrospective analysis.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sensorimotor impairments-such as reduced gait speed, diminished balance, and lower muscle strength-are common in older adults and have been suggested as early markers of cognitive decline. However, evidence from real-world hospital settings remains limited. This study investigated the associations between multiple sensorimotor functions and cognitive performance in hospitalized older adults. Methods: A retrospective cross-sectional study was conducted among 548 inpatients aged ≥ 60 years. Sensorimotor measures included gait speed, Timed Up and Go (TUG), handgrip strength, balance score, and activities of daily living (ADL). Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). Correlations were analyzed using Pearson coefficients, followed by multivariable linear and logistic regression models adjusting for demographic, clinical, and laboratory covariates. Results: Only handgrip strength showed a significant positive correlation with MMSE score ( Conclusion: In this real-world hospital cohort, sensorimotor measures were not independently associated with continuous MMSE performance after adjustment. However, gait speed was associated with cognitive impairment status in the fully adjusted logistic regression model, suggesting limited utility of routine sensorimotor assessments for cognitive screening during acute hospitalization. These findings should be interpreted cautiously given the retrospective, single-center design and potential measurement variability during hospitalization.
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