ArticleFrontiers in aging neuroscience2026
Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
Background: Perivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural alterations. This study aimed to compare cross-sectional and longitudinal trajectories of diffusion kurtosis imaging ALPS (DKI-ALPS) and DTI-ALPS and investigate their association with white matter (WM) microstructural integrity, free water (FW), Aβ burden, and cognitive impairment (CI). Methods: This study included 128 healthy controls (HCs) and 83 individuals with cognitive impairment (CI) who underwent multi-shell diffusion-weighted magnetic resonance imaging (dMRI). Four dMRI indices were quantified: DTI-ALPS and DKI-ALPS to assess the GS function; peak width of skeletonized mean diffusivity (PSMD) to evaluate the WM microstructural integrity; and FW-WM to quantify the extracellular fluid accumulation in WM. Cohen's Results: CIs exhibited significantly lower DTI-ALPS (1.28 vs. 1.37; Conclusion: Our study indicated that DKI-ALPS provides an accurate assessment of GS function compared with DTI-ALPS. Longitudinal trajectories, particularly the trajectory of DKI-ALPS, demonstrate stronger associations with Aβ burden and cognitive decline.
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