Trial reportDrug design, development and therapy2026
Efficacy of Liposomal Bupivacaine for Anterior Quadratus Lumborum Block in Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine combined with bupivacaine (LB) versus bupivacaine combined with dexamethasone (BD). Methods: In this randomized controlled trial, 136 patients undergoing laparoscopic hysterectomy or myomectomy were randomized to receive anterior QLB with either LB or BD. The primary outcome was cumulative oxycodone consumption within 48 h postoperatively. Secondary outcomes included oxycodone use across predefined postoperative intervals, resting and cough numerical rating scale (NRS) pain scores, pain area under the curve (AUC), opioid-free proportion within 72 h, duration of analgesia, and postoperative adverse events. Results: 67 LB and 69 BD patients completed the study. Cumulative 48-h oxycodone consumption was comparable between the two groups (1 mg [0-3] vs. 2 mg [0-6], Conclusion: Liposomal bupivacaine combined with bupivacaine did not reduce opioid consumption or improve analgesic outcomes compared with bupivacaine-dexamethasone for anterior QLB in laparoscopic gynecological surgery. Both regimens provided effective and well-tolerated analgesia. Trial Registration: Chinese Clinical Trials Registry Platform (chictr.org.cn): ChiCTR2500096893.
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