Evidence map›Paper›PMID 41868107›Full record

ArticleRSC chemical biology2026

Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity.

Jayanta Kundu, Dhrubajyoti Datta, Masaaki Akabane-Nakata, Soham Mandal, Monika Krampert, Martin Egli, Muthiah Manoharan

Abstract read
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jayanta KunduAlnylam Pharmaceuticals 675 West Kendall Street Cambridge MA 02142 USA mmanoharan@alnylam.com.ORCID https://orcid.org/0000-0003-2669-8112
Dhrubajyoti DattaAlnylam Pharmaceuticals 675 West Kendall Street Cambridge MA 02142 USA mmanoharan@alnylam.com.ORCID https://orcid.org/0000-0003-2077-1294
Masaaki Akabane-NakataAlnylam Pharmaceuticals 675 West Kendall Street Cambridge MA 02142 USA mmanoharan@alnylam.com.
Soham MandalAxolabs GmbH, Fritz-Hornschuch-Strasse 9 95326 Kulmbach Germany.
Monika KrampertAxolabs GmbH, Fritz-Hornschuch-Strasse 9 95326 Kulmbach Germany.
Martin EgliDepartment of Biochemistry, Vanderbilt University, School of Medicine Nashville TN 37232 USA.ORCID https://orcid.org/0000-0003-4145-356X
Muthiah ManoharanAlnylam Pharmaceuticals 675 West Kendall Street Cambridge MA 02142 USA mmanoharan@alnylam.com.ORCID https://orcid.org/0000-0002-7931-1172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5'-(

Identifiers

PMID41868107
PMCPMC13003969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.