ArticleJournal of oral microbiology2026
Dihydromyricetin attenuates biofilm formation and virulence in Streptococcus mutans, the key pathogen underlying dental caries.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Objective: Methods: Antibacterial activity was determined by minimum inhibitory concentration (MIC) and growth assays. Biofilm formation, metabolic activity and viable counts were assessed using crystal violet staining, MTT and CFU assays. Biofilm architecture was examined by electron and confocal microscopy. Acid production, extracellular polysaccharide (EPS) synthesis, adhesion and aggregation were evaluated. Expression of virulence genes ( Results: DHM showed an MIC of 250 μg/mL and significantly inhibited biofilm formation, EPS synthesis, acid production, adhesion and aggregation. Biofilm structure was disrupted and viable cell counts were reduced. DHM markedly downregulated virulence-associated and quorum sensing-related genes. Conclusion: DHM suppresses biofilm formation and cariogenic virulence of
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