ArticleCancer heterogeneity and plasticity2025
Regulation of Cancer Stem Cells in the Tumor Microenvironment.
Article in Cancer heterogeneity and plasticity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cancer stem cells (CSCs) represent a subpopulation of cancer cells characterized by their capacity for self-renewal, differentiation, and tumorigenicity. CSCs exist along a spectrum of stemness regulated by both intrinsic factors and extrinsic signals from the tumor microenvironment (TME). The TME is composed of diverse cell types such as stromal and immune cells, and also physical factors such as the extracellular matrix and hypoxia. Environmental signals originating from the TME can induce non-CSCs to acquire stem-like traits, while CSCs in turn modulate the TME by recruiting and reprogramming immune and stromal cells. Analogous to normal stem cell niches, CSCs reside in or construct supportive niches that promote stemness, metastasis, immune evasion, and therapy resistance. This reciprocal interaction between CSCs and the TME underscores the complexity of cancer stemness and presents challenges and opportunities for therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.