ArticleInternational journal of women's health2026
East Asian Mendelian-Randomization Evidence Linking PCOS to Gestational Diabetes Mellitus.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Previous Mendelian randomization (MR) studies explored causal links between polycystic ovary syndrome (PCOS) and pregnancy complications and adverse outcomes mainly in European populations, with limited generalizability. This two-sample MR study addresses this limitation. Methods: Independent genetic instruments for PCOS were selected at genome-wide significance ( Results: Genetically predicted PCOS was causally linked to increased GDM risk (OR=1.203, 95% CI: 1.00-1.433), with consistent evidence across debiased IVW (OR=1.207, 95% CI: 1.008-1.444), Bayesian Weighted MR (OR=1.204, 95% CI: 1.007-1.440), Contamination Mixture (OR=1.231, 95% CI: 1.141-1.526), and distortion test (OR=1.203, 95% CI: 1.120-1.291). The strongest single nucleotide polymorphisms (SNP)-level effect was observed for rs1894116 (YAP1), followed by rs2268361 (FSHR). MVMR confirmed independence from body mass index (BMI), though the effect disappeared after adjusting for glucose and lipid traits. No causal relationships were found between PCOS and other outcomes ( Conclusion: This MR study provides evidence supporting a potential causal association between genetically predicted PCOS and GDM in East Asian populations, in contrast to previous European-based findings, and highlights possible population-specific genetic differences with implications for precision risk assessment in pregnancy.
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