ArticleInternational journal of women's health2026
Association of Increased Fetal Fraction with Birthweight Discordance and Selective Fetal Growth Restriction: A Retrospective Study.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Twin pregnancies are at increased risk for selective fetal growth restriction (sFGR) and birthweight discordance, which contribute to elevated perinatal mortality and morbidity. Early identification of at-risk pregnancies remains challenging, limiting optimal prenatal counselling and timely clinical intervention. Objective: To determine whether fetal fraction (FF) from cell-free fetal DNA (cffDNA) screening correlates with birthweight differences and predicts birthweight discordance and sFGR in twin pregnancies. Methods: This retrospective study included 224 twin pregnancies (both dichorionic and monochorionic twins) that underwent cffDNA aneuploidy screening and delivered at the International Peace Maternity and Child Health Hospital in Shanghai between 2018 and 2021. FF values and neonatal birthweights were collected and analyzed for correlations and predictive accuracy. Results: FF showed significant positive correlation with inter-twin birthweight differences (β=0.365, 95% CI: 0.122~0.608). For every 1% increase in the FF, the difference in the birthweight between twins increased by 0.365%. A higher FF was significantly associated with an increased risk of birthweight discordance of 20% (adjusted OR: 1.073, 95% CI: 1.009~1.142), 25% (adjusted OR: 1.092, 95% CI: 1.006~1.185), and sFGR (adjusted OR: 1.130, 95% CI: 1.038~1.231). Using ROC analysis, we obtained optimum cut-off points for FFs ≥11.790 and ≥14.800 for birthweight discordance of 20% and sFGR, respectively. Compared with women with FFs of <11.790, there was a 1.091-fold higher risk of birthweight discordance of 20% (adjusted OR: 2.091, 95% CI: 1.218~3.591) when the FF was ≥11.790. There were also significantly increased risks of birthweight discordance of 25% (adjusted OR: 3.045, 95% CI: 1.297~7.149) and sFGR (adjusted OR: 3.526, 95% CI: 1.443~8.618) among women with FFs of ≥14.800. Conclusion: FF demonstrates strong positive correlation with birthweight differences and represents a novel predictive biomarker for birthweight discordance and sFGR in twin pregnancies. This accessible parameter from routine prenatal screening enables cost-neutral risk stratification and individualized pregnancy monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.