Evidence map›Paper›PMID 41867989›Full record

ReviewFrontiers in psychology2026

The prospect of suicide biomarkers: from neurobiology to precision prevention.

Na Ren, Siqian Zheng, Yixin Zhou, Xiaoling Zhang, Mini Han Wang, Ying Bian

Abstract readReview
In one paragraph

Review in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Na RenState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
Siqian ZhengState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
Yixin ZhouState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
Xiaoling ZhangGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, China.
Mini Han WangFaculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China.
Ying BianState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suicide remains a global public health crisis, accounting for over 720,000 deaths annually. Despite progress in identifying risk factors and developing theoretical frameworks, suicide continues to be a complex biopsychosocial phenomenon that eludes comprehensive understanding. This review synthesizes current evidence on the neurobiological underpinnings of suicidal behavior, encompassing genetic and epigenetic vulnerabilities, systemic physiological dysregulations, and structural and functional brain alterations. Furthermore, it critically evaluates recent advances in biologically-targeted interventions and assesses the translational potential of biomarker research for precision psychiatry. While these developments provide promising avenues for objective risk stratification and targeted treatments, significant challenges persist in bridging the gap between scientific discovery and clinical implementation. By integrating evidence across these disciplines, this review aims to provide clinicians and researchers with a comprehensive reference to inform clinical practice and guide future research directions.

Indexed as

genetic susceptibilityinterventionneurobiologyneuroimagingpreventionsuicide

Identifiers

PMID41867989
PMCPMC12999456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.