Evidence map›Paper›PMID 41867953›Full record

ArticleFrontiers in chemistry2026

Salvianolic acid B attenuates cellular senescence and age-related decline in muscle function via dual mTOR/TP53INP2-autophagy regulation.

Kaixin Liang, Mengying Hu, Hejing Zhao, Waner Xu, Yihan Zhang, Ruikun He, Cheng Peng, Hansen Chen, Zhenyu Ju, Shu Wu and 1 more

Abstract read
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In one paragraph

Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaixin LiangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Mengying HuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Hejing ZhaoState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Waner XuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Yihan ZhangBYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Ruikun HeBYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Cheng PengDepartment of Geriatrics, National Key Clinical Specialty, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Hansen ChenKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental & Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Zhenyu JuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Shu WuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
Yuanlong GeState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The rapid aging of the global population and the high prevalence of age-related diseases have positioned anti-aging as a critical research priority. Natural products have recently gained significant attention in anti-aging research owing to their multi-target and multi-pathway mechanisms, high safety profiles, and substantial potential for practical ap-plications. Methods: We performed Results: Research has demonstrated that SAB effectively alleviates the cellular senescence phenotype. It was observed that SAB reduces SASP expression through modulation of the mTOR pathway. Additionally, SAB was found to decrease cellular ROS levels and enhance ATP production. Conclusion: The study demonstrates that SAB exerts beneficial effects on cellular aging markers, including SASP, ROS, and ATP levels, and alleviates age-related decline in muscle function.

Indexed as

Autophagycellular senescencemuscleSalvianolic acid BSASP

Identifiers

PMID41867953
PMCPMC13000926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.