ReviewJournal of pharmaceutical analysis2026
Astrocytes: Unveiling their role in the molecular mechanism of natural antidepressants.
Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Natural Products as GPCR-Targeting Antidepressant Candidates: Advances and Opportunities.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Peptide-Based Nanocomplexes Enable Transferrin-Mediated Uptake and p53-Driven Antitumor Activity in 2D and 3D Glioblastoma Models.International journal of molecular sciences · 2026Article
- Vascular-associated bacterial burden and neuroinflammatory transcriptional responses observed in models of pneumonic plague.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression, an emotional disorder characterized by persistent low mood and loss of pleasure, can be alleviated by mainstream clinical drugs (such as selective serotonin reuptake inhibitors). However, issues such as delayed efficacy, significant individual differences, and adverse reactions remain. Compared to traditional single-target drugs, natural products have shown unique potential in depression intervention due to their synergistic multi-component effects and multi-target, multi-pathway regulation. As the most abundant glial cells in the central nervous system, astrocytes are deeply involved in the pathology of depression and have become important targets for the antidepressant effects of natural products. Although existing studies have revealed the regulatory effects of natural products on the function of astrocytes, there is still a lack of systematic categorization and mechanism integration. This review comprehensively summarized the molecular mechanisms by which natural products regulated astrocyte function through a systematic literature review, objectively analyzes key bottlenecks in current translational research, and aims to provide a theoretical basis and technical pathway for optimizing depression treatment paradigms and promoting the clinical translation of natural product research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.