Evidence map›Paper›PMID 41867876›Full record

ArticlebioRxiv : the preprint server for biology2026

High-pH NMR to Identify Macromolecular Hydrogen-Bonds and Foldons.

Andrei T Alexandrescu, Antonio J Rua, Sameena Shah, Daniel Fairchild, Irina Bezsonova

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Andrei T AlexandrescuDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269.ORCID 0000-0002-8425-9276
Antonio J RuaDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269.ORCID 0009-0001-5823-9706
Sameena ShahDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269.ORCID 0000-0002-8236-6465
Daniel FairchildDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06032.ORCID 0000-0001-9191-1149
Irina BezsonovaDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06032.ORCID 0000-0002-8629-0349

Funding

Understanding the Protein:Protein Interactions Required for Virus AssemblyR01GM076661 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI TESCHKE, CAROLYN M · 2007 to 2022
$7.2M
UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASER35GM156397 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Irina Bezsonova · 2025 to 2026
$1000k
NIGMS NIH HHS R01 GM076661NIGMS NIH HHS R35 GM156397
6 · The paper itself

Abstract

Hydrogen bond (H-bond) restraints are critical for NMR structure determination, yet their experimental identification can be challenging for marginally stable structures that afford insufficient protection from (H/D) exchange in D

Indexed as

conformational transitionsdenaturationfolding intermediateprotein foldingresidual structure

Identifiers

PMID41867876
PMCPMC13001501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.