ArticlebioRxiv : the preprint server for biology2026
MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney Disease.
Chenjian Gu, Yili Fang, Yixuan Wang, Eric Tycksen, Gayathri Kondepati, Chuang Li, Kendrah Kidd, Jun Liu, Fumihiko Urano, Maria Lindahl and 4 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
Chenjian Gu
Yili Fang
Yixuan Wang
Eric Tycksen
Gayathri Kondepati
Chuang Li
Kendrah Kidd
Jun Liu
Fumihiko Urano
Maria Lindahl
Anthony J Bleyer
Srikanth Singamaneni
Zhao Sun
Ying Maggie Chen
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MUAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MTherapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHNAPER, H WILLIAM · 2018 to 2022
$5.7MThe Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7MPODOCYTE ENDOPLASMIC RETICULUM STRESS AND NEPHROTIC SYNDROMER01DK105056 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, YING MAGGIE · 2017 to 2025
$4.5MUAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Javier A. Neyra · 2023 to 2026
$4.4MMutant Laminin Chains and Nephrotic SyndromeK08DK089015 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, YING MAGGIE · 2010 to 2014
$641kUltrabright Plasmonic-Fluor Nanosensor-Enabled Noninvasive Management of Pediatric Nephrotic SyndromeR21DK131557 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, YING MAGGIE, SINGAMANENI, SRIKANTH · 2022 to 2022
$236kDevelop Autophagy Activators to Treat Autosomal Dominant Tubulointerstitial Kidney DiseaseR56DK138158 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, YING MAGGIE · 2024 to 2024
$200kPHARMACOLOGICAL RESCUE OF MUTANT LAMININ IN NEPHROTIC SYNDROMER03DK106451 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, YING MAGGIE · 2015 to 2016
$153kBLRD VA I01 BX006401NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR074992NIDDK NIH HHS K08 DK089015NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK114857NIDDK NIH HHS R01 DK105056NIDDK NIH HHS R03 DK106451NIDDK NIH HHS R21 DK131557NIDDK NIH HHS R56 DK138158NIDDK NIH HHS U54 DK137307
6 · The paper itselfAbstract
Autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD) is one of the leading hereditary kidney diseases. Currently there is no targeted treatment. To illuminate human relevance of mesencephalic astrocyte-derived neurotrophic factor (MANF)-based therapy, we have established patient induced pluripotent stem cell (iPSC)-derived kidney organoid model carrying UMOD p.H177-R185del, the leading mutation causing ADTKD. We have discovered that MANF can directly bind and repress ER calcium release channel IP3R1, thus enhancing AMPK-induced autophagy in a TRIB3-dependent manner. The therapeutic implication of this finding may well be extended to other protein misfolding diseases.
Identifiers
PMID41867867
PMCPMC13001489
What OpenQuestion holds
Textmetadata
Read underepoch 390