Evidence map›Paper›PMID 41867860›Full record

ArticlebioRxiv : the preprint server for biology2026

Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice.

Mi-Kyung Shin, Arijit Roy, Omkar Padel, Samhita Gudapati, James Sk Sham, Wan-Yee Tang, Vsevolod Y Polotsky

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mi-Kyung ShinDepartment of Anesthesiology and Critical Care Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC.ORCID 0000-0003-0755-157X
Arijit RoyDepartment of Anesthesiology and Critical Care Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC.
Omkar PadelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Samhita GudapatiDepartment of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA.
James Sk ShamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Wan-Yee TangDepartment of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA.
Vsevolod Y PolotskyDepartment of Anesthesiology and Critical Care Medicine, School of Medicine and Health Sciences, George Washington University, Washington, DC.

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
NHLBI NIH HHS R01 HL133100
6 · The paper itself

Abstract

Obesity is the most common cause of hypertension. We have previously shown that high levels of circulating leptin in diet-induced obese (DIO) mice induced hypertension by increasing expression of Transient Receptor Potential Melastatin-subfamily member 7 (TRPM7) in the carotid bodies (CB). In addition, we demonstrated in rat PC12 cells that leptin increases

Identifiers

PMID41867860
PMCPMC13001396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.