Evidence map›Paper›PMID 41867856›Full record

ArticlebioRxiv : the preprint server for biology2026

Tmn blocks phage spread via plasmolysis and triggers synergistic defence responses.

Yi Wu, Zhiying Zhang, Sofya K Garushyants, Ruizhe Li, Regan Doherty, James A Milton, Matthew J Cooper, Yilmaz Emre Gençay, Triana Amen, Somenath Bakshi and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yi WuSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Zhiying ZhangStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sofya K GarushyantsDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Ruizhe LiDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge, UK.
Regan DohertyBiomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
James A MiltonSchool of Ocean and Earth Science, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Matthew J CooperSchool of Ocean and Earth Science, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Yilmaz Emre GençaySNIPR Biome, Copenhagen, Denmark.
Triana AmenSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Somenath BakshiDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge, UK.ORCID 0000-0003-3864-2546
Dinshaw J PatelStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eugene V KooninDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Franklin L NobregaSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-8238-1083

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Structure-Activity Based Mechanistic Insights into Cleavage Chemistry by Self-Cleaving Nucleolytic RibozymesR01GM145888 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PATEL, DINSHAW J · 2022 to 2025
$1.3M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM145888NIGMS NIH HHS U24 GM129539Wellcome Trust
6 · The paper itself

Abstract

Membrane-associated phage defences remain poorly understood. Here we characterise Tmn, a YobI-family transmembrane P-loop NTPase that protects bacteria from phage infection by establishing a plasmolysis-associated antiviral state. Upon recognising phage T2 RIIB protein, Tmn enhances ATP turnover and selectively exports Mg

Identifiers

PMID41867856
PMCPMC13001434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.