Evidence map›Paper›PMID 41867855›Full record

ArticlebioRxiv : the preprint server for biology2026

RNA G-quadruplexes mediate cooperativity in HNRNPH binding and splicing regulation.

Kerstin Tretow, Mario Keller, Mikhail Mesitov, Miona Ćorović, Mirko Brüggemann, Jonas Busam, Farica Zhuang, Nadine Körtel, Nicolas Melchior, Anke Busch and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kerstin TretowInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Mario KellerBuchmann Institute for Molecular Life Sciences (BMLS) & Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany.
Mikhail MesitovInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Miona ĆorovićInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Mirko BrüggemannBuchmann Institute for Molecular Life Sciences (BMLS) & Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany.
Jonas BusamTheodor Boveri Institute, Julius Maximilians University Würzburg, Biocenter, Am Hubland, 97074 Würzburg, Germany.
Farica ZhuangDepartment of Computer and Information Science, University of Pennsylvania, 3330 Walnut Street, Philadelphia, PA 19104, USA.
Nadine KörtelInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Nicolas MelchiorInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Anke BuschInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Simon BraunInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Nadja HellmannDepartment of Chemistry, Biochemistry, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany.
Heike HänelInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Pol BeseniusDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Susanne StrandDepartment of Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 63, 55131 Mainz, Germany.
Yoseph BarashDepartment of Computer and Information Science, University of Pennsylvania, 3330 Walnut Street, Philadelphia, PA 19104, USA.ORCID 0000-0003-3005-5048
Stefan LegewieUniversity of Stuttgart, Institute of Biomedical Genetics (IBMG) & Stuttgart Research Centre Systems Biology (SRCSB), Allmandring 31, 70569 Stuttgart, Germany.
Friederike SchmidInstitute of Physics, Johannes Gutenberg University Mainz, Staudingerweg 7-9, 55128 Mainz, Germany.
Julian KönigInstitute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany.
Kathi ZarnackBuchmann Institute for Molecular Life Sciences (BMLS) & Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany.ORCID 0000-0003-3527-3378

Funding

Identifying regulatory uORFs as a targetable axis for hereditary diseaseR01GM147739 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARASH, YOSEPH, HAND, NICHOLAS JOSEPH · 2022 to 2025
$1.7M
Methods for improving clinical diagnostic by detection, prediction, interpretation and prioritization of aberrant transcriptome variationsR01LM013437 · NLM · UNIVERSITY OF PENNSYLVANIA · PI BARASH, YOSEPH · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM147739NLM NIH HHS R01 LM013437
6 · The paper itself

Abstract

Alternative splicing, regulated by RNA-binding proteins (RBPs), enables the generation of diverse transcript isoforms critical for cellular function. However, how RNA secondary structure impacts RBP binding and function remains poorly understood. Here, we unravel how RNA G-quadruplexes (rG4s) facilitate cooperativity in splicing regulation by the RBP heterogeneous nuclear ribonucleoprotein H (HNRNPH). Through high-throughput

Indexed as

alternative splicingantisense oligonucleotidescancercooperative regulationG4HNRNPHiCLIPmathematical modellingRNA G-quadruplexRNA structureRTstop profiling

Identifiers

PMID41867855
PMCPMC13001508

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.