In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Zidong ZhangDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-6917-8195 German NudelmanDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hanna PincasDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gayatri IyerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Gregory R SmithDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0112-6134 Hasmik KeshishianProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Christopher A JinDepartment of Genetics, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7340-5023 Daniel H KatzDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7237-8502 Venugopalan D NairDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8231-6230 Elena ZaslavskyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-4828-7771 Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-5791-1217 MoTrPAC Study Group
Funding
MoTrPAC Supplemental Funding for MillerU24AR071113 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jon Peter Durda, Karyn A Esser · 2017 to 2026
$28.8MResearch BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5MPAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STUART C. SEALFON, Martin John Walsh · 2017 to 2026
$18.5MStanford/Salk MoTrPAC Site for Genomes, Epigenomes and TranscriptomesU24DK112348 · NIDDK · STANFORD UNIVERSITY · PI Stephen Montgomery, MICHAEL P. SNYDER · 2017 to 2026
$18.4MMolecular Transducers of Physical Activity Consortium Adult Clinical CenterU01AR071130 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUSI, NICOLAS, RASMUSSEN, BLAKE B · 2017 to 2024
$17.7MProMoTr: A Proteomics Center for MoTrPACU24DK112349 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Joshua N. Adkins · 2017 to 2026
$17.5MThe Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7MA Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2MMoTrPAC DXA Quality ControlU01AR071128 · NIAMS · DUKE UNIVERSITY · PI HOUMARD, JOSEPH A, KRAUS, WILLIAM E · 2017 to 2025
$15.2MMolecular Transducers of Physical Activity Consortium - Colorado Clinical CenterU01AR071124 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2017 to 2024
$14.5MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jonathan Adam Letterman Gelfond · 2015 to 2026
$14.1MStanford MoTrPAC Bioinformatics CenterU24OD026629 · OD · STANFORD UNIVERSITY · PI ASHLEY, EUAN A, WHEELER, MATTHEW THOMAS · 2018 to 2023
$13.9MBLRD VA I01 BX003271BLRD VA IK6 BX007133NEI NIH HHS R01 EY030546NHGRI NIH HHS R01 HG009299NHLBI NIH HHS K01 HL177266NHLBI NIH HHS K23 HL150327NHLBI NIH HHS K23 HL164980NHLBI NIH HHS K23 HL177335NHLBI NIH HHS R00 HL159241NHLBI NIH HHS R01 HL133870NIAMS NIH HHS U01 AR071124NIAMS NIH HHS U01 AR071128NIAMS NIH HHS U01 AR071130NIAMS NIH HHS U01 AR071133NIAMS NIH HHS U01 AR071150NIAMS NIH HHS U01 AR071158NIAMS NIH HHS U01 AR071160NIAMS NIH HHS U24 AR071113NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG094848NIA NIH HHS R01 AG066474NIA NIH HHS R01 AG089069NIA NIH HHS U01 AG055133NIA NIH HHS U01 AG055135NIA NIH HHS U01 AG055137NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK081572NIDDK NIH HHS U24 DK112326NIDDK NIH HHS U24 DK112331NIDDK NIH HHS U24 DK112340NIDDK NIH HHS U24 DK112341NIDDK NIH HHS U24 DK112342NIDDK NIH HHS U24 DK112348NIDDK NIH HHS U24 DK112349NIGMS NIH HHS T32 GM135066NIH HHS R03 OD038387NIH HHS U24 OD026629NINR NIH HHS R01 NR019628
6 · The paper itselfAbstract
The diverse health benefits of exercise are associated with multi-organ molecular responses. Alternative RNA splicing (AS) is an important determinant of transcriptome and proteome diversity. We profiled the temporal effects of acute endurance and resistance exercise on the AS landscape of human skeletal muscle, adipose tissue, and blood, and studied regulatory mechanisms through integrated multi-omic analyses. We identified 5102 distinct differential AS (DAS) events, with the majority modifying protein-coding sequence (89%) and being independent of altered RNA expression (67%). Endurance and resistance exercise induced differing patterns of AS alterations with divergent temporal trajectories. We inferred the DAS-associated RNA-binding and DNA-binding proteins. In skeletal muscle, where DAS events were the most abundant, DAS genes were enriched for muscle structure- and RNA splicing-related processes, and splicing machinery components were regulated at the protein phosphorylation, RNA, and AS levels. These findings implicate AS regulation as a major mediator of the responses to exercise.
Indexed as
acute endurance exerciseacute resistance exerciseadipose tissuealternative splicingbloodepigenomephosphoproteomeproteomeskeletal musclespliceosome
Identifiers
PMID41867854
PMCPMC13001507
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