Evidence map›Paper›PMID 41867847›Full record

ArticlebioRxiv : the preprint server for biology2026

Activation of TPC2 amplifies lysosome-mitochondria calcium transfer to regulate energetic stress responses.

Sadia Ahmed, Namratha Javvaji, Katherine L Hammond, Kevin M Casin, John W Elrod, Paul M Holloway, Yvonne Couch, Jillian N Simon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sadia AhmedAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Namratha JavvajiAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Katherine L HammondDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, L6 West Wing, Oxford OX3 9DU, UK.ORCID 0009-0002-4663-671X
Kevin M CasinAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0003-3734-6075
John W ElrodAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0003-3925-2224
Paul M HollowayAcute Stroke Program, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.ORCID 0000-0002-1947-4885
Yvonne CouchAcute Stroke Program, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.ORCID 0000-0002-5623-5568
Jillian N SimonAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0001-8140-7782

Funding

Lysosomal ionic dysregulation in heart diseaseR01HL180055 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Jillian Noelle Simon · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL180055
6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

calciuminter-organelle communicationlysosomemPTP openingmtCUstroke

Identifiers

PMID41867847
PMCPMC13001433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.