Evidence map›Paper›PMID 41867841›Full record

ArticlebioRxiv : the preprint server for biology2026

Generation of a new immunodeficient rat model of retinal degeneration with LSL TdTomato reporter and TdTomato-Pcp2 expression.

Magdalene J Seiler, Helios Nguyen, Devan Endejan, Bin Lin, Guojun Zhao, Lauren Klaskala

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Magdalene J SeilerDepartment of Physical Medicine & Rehabilitation; Sue & Bill Stem Cell Research Center; University of California, Irvine, U.S.A.ORCID 0000-0002-0869-9923
Helios NguyenDepartment of Physical Medicine & Rehabilitation; Sue & Bill Stem Cell Research Center; University of California, Irvine, U.S.A.ORCID 0009-0007-6963-2785
Devan EndejanInotiv, Maryland Heights, MO, 63043, USA.
Bin LinDepartment of Physical Medicine & Rehabilitation; Sue & Bill Stem Cell Research Center; University of California, Irvine, U.S.A.ORCID 0000-0001-7043-5788
Guojun ZhaoInotiv, Maryland Heights, MO, 63043, USA.
Lauren KlaskalaInotiv, Maryland Heights, MO, 63043, USA.ORCID 0009-0002-7594-6098

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2007 to 2016
$25.1M
NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Integration and functionality of retinal organoid transplantsR01EY031834 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEILER, MAGDALENE J · 2021 to 2025
$3.0M
Retinal sheet transplant impact on functional organization of visual cortex in retinal degenerate animal modelsR01EY032948 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYON, DAVID C, SEILER, MAGDALENE J · 2022 to 2025
$2.3M
NCI NIH HHS P30 CA062203NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY031834NEI NIH HHS R01 EY032948NIGMS NIH HHS P50 GM076516
6 · The paper itself

Abstract

Purpose: To develop an immunodeficient retinal degenerate (RD) rat model with fluorescent label for studying retinal degeneration and transplant-host connectivity. Methods: Gene constructs for Results: TdTomato-Pcp2 RD rats exhibit RD similar to the original Conclusions: We created an unique RD rat model for studying retinal transplant connectivity. The RD Translational relevance: This newly created rat model is useful for cell therapy studies.

Indexed as

bipolar cellscre-lox cell labelcre-recombinasePhotoreceptor degenerationtransgenic rat

Identifiers

PMID41867841
PMCPMC13001490

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.