In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Helen I Warheit-NiemiPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.ORCID 0000-0001-5038-264X Jessie HuangHastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.ORCID 0000-0002-5297-3563 Kathleen C S CookPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.ORCID 0009-0007-0850-9353 Konstantinos-Dionysios AlysandratosCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0000-0002-5611-0343 Sharlene FernandesPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Payel BasakCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0009-0001-9519-1991 Barbara ZhaoPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Eitan VilkerCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0009-0004-0672-1973 Carlos Villacorta-MartinCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.
Amber ElitzPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Pushpinder BawaCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0000-0002-8370-3638 Michael J HerrigesCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0000-0002-7842-9515 Darrell N KottonCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA USA.ORCID 0000-0002-9604-8476 William J ZachariasPerinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA.ORCID 0000-0002-2643-0610 Funding
Patient-specific iPSCs to model and treat the inception of pulmonary fibrosisP01HL170952 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2024 to 2026
$11.4MScientific Human Biomarker Exposure Monitoring Core (HEMC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) StudyP01HL152953 · NHLBI · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2021 to 2025
$9.8MDerivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5MPulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3MPrdm3/16 Regulate Chromatin Accessibility to Determine Alveolar MaturationR01HL164414 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A · 2022 to 2025
$2.8MEpigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.R01HL156860 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA, ZACHARIAS, WILLIAM JOHN · 2021 to 2025
$1.9MBIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS (BHIPSC-LUNG). IPSC TASK AREA B - SCIENTIFIC PROJECTS75N92025D00035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2025 to 2025
$732kUtilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosisK08HL163494 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Konstantinos Alysandratos · 2023 to 2026
$649kNHLBI NIH HHS K08 HL163494NHLBI NIH HHS P01 HL152953NHLBI NIH HHS P01 HL170952NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL156860NHLBI NIH HHS R01 HL164414NHLBI NIH HHS T32 HL007752NIH HHS 75N92025D00035
6 · The paper itselfAbstract
Maintenance of the gas exchange surface throughout life and regeneration of the lung after injury requires tight regulation of epithelial cell fate and function. Alveolar epithelial type 2 (AT2) cells serve as the progenitors of the distal epithelium, differentiating into alveolar epithelial type 1 (AT1) cells or proliferating to maintain the quorum of AT2 cells. Here we describe the role of the chromatin regulator polycomb repressive complex 2 (PRC2) in the maintenance of AT2 cell fate in the adult alveolus. Cross-species single-cell transcriptomic analyses identified PRC2 activation in proliferative AT2 populations. PRC2 loss of function in human iPSC-derived AT2 (iAT2) cells and primary murine AT2 cells
Identifiers
PMID41867819
PMCPMC13001458
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