Evidence map›Paper›PMID 41867808›Full record

ArticlebioRxiv : the preprint server for biology2026

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication.

Amber Crabtree, Suraj Thapliyal, Mohd Mabood Khan, Edgar Garza Lopez, Andrea Marshall, Calixto Pablo Hernandez Perez, Oleg Kovtun, Jenny C Schafer, Dea Pulatani, Yuho Kim and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Amber CrabtreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Suraj ThapliyalDepartment of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.
Mohd Mabood KhanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Edgar Garza LopezDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Andrea MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Calixto Pablo Hernandez PerezDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Oleg KovtunDepartment of Chemistry, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0000-0001-6809-9332
Jenny C SchaferDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.
Dea PulataniDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Yuho KimDepartment of Physical Therapy and Kinesiology, University of Massachusetts Lowell, Lowell, MA, USA.
Sepiso K MasengaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Annet KiraboDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Jeremiah AfolabiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Melanie McReynoldsThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Renata O PereiraDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Prasanna VenkhateshDepartment of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.
Prasanna KattiDepartment of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.
Brian GlancyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7730-952X

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
PRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2M
Spinning Disk Super Resolution Confocal Microscope for the Vanderbilt Brain InstituteS10MH130456 · NIMH · VANDERBILT UNIVERSITY · PI SCHAFER, JENNY · 2023 to 2023
$598k
NHLBI NIH HHS R25 HL106365NIDDK NIH HHS P30 DK020593NIMH NIH HHS S10 MH130456
6 · The paper itself

Abstract

Mitochondrial structural plasticity is a critical adaptive response to cellular stress, yet the transcriptional networks governing the formation of specialized mitochondrial architectures remain poorly defined. Here, we identified and demonstrated that activating transcription factor 4 (ATF4), the master regulator of the integrated stress response, directly regulates mitochondrial morphological remodeling through a novel ATF4-NRF1/Nrf2-MFN2 signaling axis. Using serial block-face scanning electron microscopy and three-dimensional reconstruction in

Indexed as

3D StructureATF4MetabolismMitochondriaStress

Identifiers

PMID41867808
PMCPMC13001514

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.