Evidence map›Paper›PMID 41867785›Full record

ArticlebioRxiv : the preprint server for biology2026

Differential control of both cell cycle-regulated and quantitative histone mRNA expression by

Mark S Geisler, James P Kemp, Christina A Hill, William F Marzluff, Robert J Duronio

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mark S GeislerCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.ORCID 0000-0002-2900-4609
James P KempIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, 27599 USA.ORCID 0000-0003-1975-1149
Christina A HillIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, 27599 USA.
William F MarzluffCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.

Funding

Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
The Mute button: Turning down the volume of histone expressionF31HD113267 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GEISLER, MARK STEPHEN · 2023 to 2025
$146k
NICHD NIH HHS F31 HD113267NIGMS NIH HHS R35 GM145258
6 · The paper itself

Abstract

Coupling histone gene expression to S phase of the cell cycle is essential for genome duplication and stability. Activation of Cyclin E/Cdk2 at the G1-S transition stimulates high-level expression of histone genes during S phase, but how histone genes are turned off at the end of S phase is not understood. Here we demonstrate that the essential

Indexed as

biomolecular condensatescell cycleDrosophilahistonestranscription

Identifiers

PMID41867785
PMCPMC13001340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.