Evidence map›Paper›PMID 41867768›Full record

ArticlebioRxiv : the preprint server for biology2026

Physiologic variation in sperm miRNAs tune embryonic gene regulatory programs and developmental outcomes.

Grace S Lee, James Garifallou, Samantha L Higgins, Katherine Z Scaturro, Adele Harman, Taylor Miller-Ensminger, Madeline N Lamonica, Liana Savarirayan, Michael C Golding, Colin C Conine

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grace S LeePharmacology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
James GarifallouDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Samantha L HigginsInterdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, TX, United States.
Katherine Z ScaturroDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Adele HarmanTransgenic Core, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Taylor Miller-EnsmingerDepartment of Genetics and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Madeline N LamonicaDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Liana SavarirayanDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michael C GoldingDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.ORCID 0000-0003-1631-2175
Colin C ConineDepartment of Genetics and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-7915-0463

Funding

HERITABLE, EPIGENETIC EFFECTS OF PATERNAL ALCOHOL USE ON FASD PHENOTYPESR01AA028219 · NIAAA · TEXAS A&M UNIVERSITY · PI Colin Conine, Michael C. Golding · 2020 to 2026
$2.3M
Determining the role of sperm microRNAs in early development and non-genetic inheritanceF31HD114433 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LEE, GRACE SUNEUY · 2024 to 2025
$89k
NIAAA NIH HHS R01 AA028219NICHD NIH HHS F31 HD114433NICHD NIH HHS L50 HD119810
6 · The paper itself

Abstract

Small RNAs delivered by sperm can transmit environmentally regulated, epigenetically inherited phenotypes to offspring, yet the mechanisms by which modest changes in sperm microRNA abundance overcome dilution within the much larger egg to influence embryonic development remain unresolved. Here, we show that physiologically relevant variation in individual sperm miRNAs is sufficient to quantitatively program embryonic gene expression and developmental outcomes. Using parthenogenetic and fertilized embryos, we show that as few as 200 molecules of

Indexed as

alcoholembryonic developmentepigenetic inheritancemiRNAsperm

Identifiers

PMID41867768
PMCPMC13001510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.