Evidence map›Paper›PMID 41867743›Full record

ArticlebioRxiv : the preprint server for biology2026

HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors.

Nirmal Kumar, Braelyn Liang, Jonathan D Geiger

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Nirmal KumarDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58203, USA.
Braelyn LiangDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58203, USA.
Jonathan D GeigerDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58203, USA.

Funding

Stress and Health in American Indian PregnanciesP20GM139759 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI STEELE, JOEL SUMMER · 2021 to 2025
$8.3M
The Role of Adenosine in Ketogenic Diet TherapyR01NS065957 · NINDS · TRINITY COLLEGE · PI BOISON, DETLEV, GEIGER, JONATHAN DAVID · 2010 to 2021
$3.9M
Effects of opiates on neurons and their impact on HIV neuropathologyR01DA032444 · NIDA · DREXEL UNIVERSITY · PI MEUCCI, OLIMPIA · 2012 to 2023
$3.8M
Tat endolysosome escape and HANDR01MH119000 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI CHEN, XUESONG, GEIGER, JONATHAN DAVID · 2019 to 2023
$2.6M
NIDA NIH HHS R01 DA032444NIGMS NIH HHS P20 GM139759NIMH NIH HHS R01 MH119000NINDS NIH HHS R01 NS065957
6 · The paper itself

Abstract

Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND). The HIV-1 envelope glycoprotein gp120 causes LSR, increases levels of ferrous iron (Fe

Indexed as

HIV-1 gp120lysosomal stress responsesreactive carbonyl speciesreactive nitrogen speciesreactive oxygen speciesreactive species interactomereactive sulfur speciesredox sensorTRPML1

Identifiers

PMID41867743
PMCPMC13001474

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.