Evidence map›Paper›PMID 41867728›Full record

ArticlebioRxiv : the preprint server for biology2026

Centromeres are hotspots of cytosine methylation epimutations in a filamentous fungus.

Mariana Villalba de la Peña, Clayton Hull-Crew, Taylor R Hutter, Cynthia A Vino, Peter Sarkies, Maria Colomé-Tatché, Frank Johannes, Andrew D Klocko, Ilkka Kronholm

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariana Villalba de la PeñaDepartment of Biological and Environmental Science, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
Clayton Hull-CrewDepartment of Chemistry & Biochemistry, University of Colorado, Colorado Springs, USA.
Taylor R HutterDepartment of Chemistry & Biochemistry, University of Colorado, Colorado Springs, USA.
Cynthia A VinoDepartment of Chemistry & Biochemistry, University of Colorado, Colorado Springs, USA.
Peter SarkiesDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-0279-6199
Maria Colomé-TatchéBiomedical Center, Division of Physiological Chemistry, Faculty of Medicine, LMU Munich, Munich, Germany.
Frank JohannesPlant Epigenomics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, 85354, Germany.
Andrew D KlockoDepartment of Chemistry & Biochemistry, University of Colorado, Colorado Springs, USA.ORCID 0000-0002-2236-672X
Ilkka KronholmDepartment of Biological and Environmental Science, University of Jyväskylä, FI-40014 Jyväskylä, Finland.ORCID 0000-0002-4126-0250

Funding

Genome topology in the filamentous fungus Neurospora crassa: organizing factors and impact on genome functionR15GM140396 · NIGMS · UNIVERSITY OF COLORADO · PI KLOCKO, ANDREW DAVID · 2020 to 2025
$607k
NIGMS NIH HHS R15 GM140396
6 · The paper itself

Abstract

Epimutations are changes in chromatin modifications, such as DNA methylation or histone modifications. Some of these epigenetic changes can be inherited for several generations, and they potentially contribute to evolutionary processes. Estimates of epimutation rates now exists in a few species, but the presence and function of epigenetic marks are not conserved across different species. To understand the properties of epimutations in fungi, we performed a mutation accumulation experiment with the filamentous fungus

Indexed as

epigeneticsepimutation ratefungiH3K9 trimethylationmutation accumulationNeurospora crassa

Identifiers

PMID41867728
PMCPMC13001447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.