ArticlebioRxiv : the preprint server for biology2026
Identification of Key Residues in Allosteric Signaling of Photoactivated Adenylyl Cyclase.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Funding
Abstract
Photoactivated adenylyl cyclases (PACs) convert ATP to cyclic AMP (cAMP) through long-range photoinduced allosteric communication between a BLUF domain and a distant adenylyl cyclase (AC) domain. Although photoactivation of the BLUF domain induces only minimal structural changes, it activates a chemical reaction about 4-5 nm away. Here, we combine molecular dynamics simulations, electronic structure calculations, network theory, and machine-learning approaches to investigate photoinduced allostery in the PAC from
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Registered trials
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