ArticlebioRxiv : the preprint server for biology2026
Peripheral B cell populations tune spontaneous neuronal activity in the uninjured hippocampus after stroke.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
B cells infiltrate the contralesional hippocampus following stroke, but whether lymphocytes modulate post-stroke plasticity and neuronal network function remains unknown. To identify immune cell mechanism(s) supporting remote plasticity, we examined the impact of B cell depletion on synaptic and neuronal activity in the hippocampal circuit following stroke. Basal synaptic transmission in the contralesional dentate gyrus (DG) following a stroke in adult male mice was decreased with B cell depletion. Expanding our studies to encompass the CA1 and DG regions of the hippocampal circuit in male and female mice of different ages, we utilized synapsin-Cre/GCaMP6s mice to visualize spontaneous calcium activity during a 3-week B cell depletion with and without prior stroke. Systemic B cell depletion in the absence of injury altered neuronal activity in the DG, suggesting a novel neuromodulatory role for circulating immune cells. Stroke increased Ca
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