ArticleNeuropsychiatric disease and treatment2026
Prevalence and Clinical Correlates of Anxiety in Chinese Outpatient Population with Somatic Symptom Disorder.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anxiety is highly prevalent among patients with Somatic Symptom Disorder (SSD) and is strongly associated with adverse outcomes. However, its associated factors remain largely unexplored. This study aimed to investigate the incidence of anxiety and its related factors in patients with SSD. Methods: A total of 899 patients with SSD were recruited. Anxiety levels were assessed using the 17-item Hamilton Anxiety scale (HAMA-17). Clinical features, including depressive and psychiatric symptoms, were measured alongside physiological measures, such as fasting blood glucose, blood pressure, lipid profiles, and thyroid levels. Binary logistic regression models were used to identify independent correlates of anxiety. Results: The prevalence of anxiety symptoms in Chinese patients with SSD is 67.41%. Compared to patients without anxiety, patients with anxiety symptoms had higher Hamilton Depression (HAMD) score, higher suicide attempt rate, psychotic symptoms, and higher levels of some physiological indicators. Binary logistic analysis indicated that HAMD score, suicide attempts, antithyroglobulin (A-TG), and diastolic blood pressure (DP) levels were correlated with anxiety symptoms in patients with SSD. Conclusion: This study highlights the high prevalence of anxiety in patients with SSD. Anxiety is associated with depression, suicide attempts, A-TG, and DP levels in patients with SSD. While causality cannot be established due to the cross-sectional design, these findings highlight potential clinical markers that may help identify patients at higher risk of anxiety and provide a basis for future longitudinal studies to explore underlying mechanisms.
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