ArticleFrontiers in nutrition2026
Dietary index for gut microbiota is inversely associated with colorectal cancer risk: a case-control study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Inflammatory, antioxidant, and gut microbiota-related dietary indices and gastric cancer risk: a case-control study.Frontiers in nutrition · 2026Article
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5 authors.
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Abstract
Background: Gut microbial dysbiosis is a recognized contributor to colorectal cancer (CRC) development, with diet serving as a primary modifiable factor influencing microbiota composition. While previous research has largely focused on individual nutrients or the inflammatory potential of diet, few studies have investigated dietary patterns explicitly designed to support gut microbiota health in relation to CRC risk. Methods: In this case-control study, 350 adults (175 newly diagnosed CRC patients and 175 age- and sex-matched controls) were recruited. Dietary intake was assessed using multiple 24-h recalls and a validated food-frequency questionnaire to calculate the Dietary Index for Gut Microbiota (DI-GM), which emphasizes prebiotic fibers, polyphenols, fermented foods, fruits, vegetables, legumes, and whole grains, while penalizing ultra-processed and pro-inflammatory foods. Anthropometric, lifestyle, inflammatory (CRP, IL-6), frailty (mFI-5), intestinal permeability, and psychological indicators were measured. Logistic regression estimated CRC odds across DI-GM tertiles, adjusting for potential confounders. Results: CRC patients had significantly lower DI-GM scores than controls (7.29 ± 2.70 vs. 11.34 ± 2.55; Conclusion: Greater adherence to a gut microbiota-supportive dietary index is independently associated with a lower risk of colorectal cancer, as well as with more favorable profiles of systemic inflammation, gut barrier integrity, and psychosocial health. These findings highlight the potential of microbiota-targeted dietary strategies for CRC prevention and support the need for future prospective and interventional research.
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