Evidence map›Paper›PMID 41867644›Full record

ArticleSovremennye tekhnologii v meditsine2026

16S rRNA Metabarcoding Used to Identify the Etiology of Infective Endocarditis Agents.

A V Sinitskaya, A E Kostunin, M V Khutornaya, A O Poddubnyak, O N Hryachkova, M A Asanov, A E Tupikin, M R Kabilov, A N Stasev, M Y Sinitsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A V SinitskayaPhD, Senior Researcher, Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
A E KostuninPhD, Senior Researcher, Laboratory of New Biomaterials, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
M V KhutornayaResearcher, Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
A O PoddubnyakLaboratory Research Assistant, Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
O N HryachkovaPhD, Researcher, Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
M A AsanovJunior Researcher, Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
A E TupikinJunior Researcher, Center for Collective Use "Genomics"; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentuev Prospekt, Novosibirsk, 630090, Russia.
M R KabilovPhD, Head of the Center for Collective Use "Genomics" Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentuev Prospekt, Novosibirsk, 630090, Russia.
A N StasevMD, PhD, Senior Researcher, Laboratory of Heart Defects, Department of Heart and Vascular Surgery; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.
M Y SinitskyPhD, Head of the Laboratory of Genomic Medicine, Department of Experimental Medicine; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Blvd., Kemerovo, 650002, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: The study material involved 20 native cardiac valve samples from 16 patients. Sequencing was carried out in the Center for Collective Use "Genomics" (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Russia) on a sequenator MiSeq (Illumina, USA) using MiSeq Reagent Kit v3 (2×300 bp; Illumina, USA). Results: The study revealed major microorganisms (their portion in the sample under study was over 5% from all identified bacterial agents) belonging to Conclusion: The findings demonstrated the efficiency of 16S rRNA metabarcoding in identifying bacterial agents compared to routine noninvasive diagnostic methods. Native cardiac valves isolated from the patients with infective endocarditis were characterized by numerous opportunistic pathogenic bacteria in negative blood cultures.

Indexed as

BacteriaDNA Barcoding, TaxonomicEndocarditis, BacterialHeart ValvesRNA, Ribosomal, 16SHumansRNA, Ribosomal, 16S16S metabarcodingbacterial agentsinfective endocarditisnative cardiac valves

Identifiers

PMID41867644
PMCPMC13003589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.