Evidence map›Paper›PMID 41867640›Full record

ArticleSovremennye tekhnologii v meditsine2026

Portable Bioprinter in Ischemic Wound Therapy: a Pilot Study.

D P Revokatova, Y I Khristidis, A L Fayzullin, B P Ershov, D I Larionov, I V Nesterenko, A I Shpichka, P S Timashev

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PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D P RevokatovaJunior Researcher, Clinical Smart Nanotechnology Laboratory, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
Y I KhristidisHead of the Laboratory of Regenerative Veterinary Medicine, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
A L FayzullinMD, PhD, Associate Professor, Head of the Laboratory of Digital Microscopic Analysis, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
B P ErshovLaboratory Assistant, Laboratory of Macromolecular Design, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
D I LarionovSoftware Engineer, Design Centre for Flexible Bioelectronics, Institute for Bionic Technologies and Engineering of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
I V NesterenkoHead of the Design Centre for Flexible Bioelectronics, Institute for Bionic Technologies and Engineering of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
A I ShpichkaPhD, Associate Professor, Head of Laboratory of Applied Microfluidics, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.
P S TimashevDSc, Professor, Center for Digital Design and Personalized Medicine; Chief Scientific Officer, Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: To simulate the wound, titanium sealing rings were used, which mechanically compressed the skin to create a local ischemic wound. A day after, the rings were removed, and the epidermis of the skin was excised. The wound was treated one day and 2 weeks after the wound infliction. For this purpose, a combined ink was applied to the wound surface using a portable Biogan bioprinter (the prototype was developed by the authors). An adapted passive mixer allowed uniform mixing of the bioink based on a fibrin-gelatin hydrogel and spheroids derived from human adipose MSCs. Wound closure rates were assessed over 36 days, followed by histological analysis. Results: The use of inks based on fibrin-gelatin hydrogel and spheroids from adipose MSCs significantly accelerated healing, as evidenced by the reduction in the wound area compared to the control group and hydrogel-only group, as well as the complete restoration of all skin layers by day 36. The therapeutic effect of the developed approach was due to the spheroids in the bioinks and not to the hydrogel. The use of the developed mixer did not reduce the cell viability and ensured convenient ink application to the wound surface.

Indexed as

BioprintingIschemiaWound HealingAdipose TissueAnimalsFibrinGelatinHumansHydrogelsMesenchymal Stem CellsPilot ProjectsSkinSpheroids, CellularSwineFibrinGelatinHydrogelsbioinkin situ bioprintingischemic woundsnon-healing woundsspheroids

Identifiers

PMID41867640
PMCPMC13003592

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.