ReviewFrontiers in dental medicine2026
Peri-implantitis: a systemic burden for our patients.
Review in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Surgical Reconstructive Therapy of Peri-Implantitis via Submerged Versus Non-Submerged Healing: A 2-Year Retrospective Study.Clinical implant dentistry and related research · 2026Article
- Article
- Editorial: From the mouth to the brain: exploring the link between periodontitis/peri-implantitis and neuroinflammation.Frontiers in cellular neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peri-implantitis-an increasingly prevalent chronic inflammatory disease-has been linked not only to peri-implant bone destruction and implant failure, but also to systemic inflammation and chronic inflammatory diseases. Accumulating evidence suggest that peri-implant inflammation can contribute to a sustained systemic low-grade inflammatory state characterized by elevated inflammatory mediators, like interleukin (IL)-6 and C reactive protein, episodic bacteremia, and metabolic alterations. This persistent inflammatory burden has been associated with distal organ dysfunction, including cardiovascular and renal complications, and neuroinflammatory processes implicated in cognitive decline and neurodegeneration. In parallel, implant-supported rehabilitation and long-term maintenance has been linked to surrogate markers of cognitive resilience, whereas treatment of peri-implant diseases aimed at reducing local inflammation may, at the same, be associated with the improvement of systemic inflammatory markers. This concise review synthesizes mechanistic and clinical evidence that peri-implantitis is not only an oral disease but also a systemic health modifier, highlights current knowledge gaps, and outlines priorities for research and clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.