SynthesisFrontiers in dental medicine2026
Cellular and molecular response of dental stem cells to decellularized extracellular matrix scaffolds in regenerative endodontics: a systematic review.
Synthesis in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Decellularized extracellular matrices (dECMs) have gained increasing attention in regenerative dentistry due to their ability to replicate aspects of the native cellular microenvironment while reducing immunogenicity. Dental-derived stem cells exhibit regenerative and immunomodulatory properties, making them promising candidates for tissue repair when combined with biologically derived scaffolds such as dECMs. Objective: This systematic review aimed to evaluate the cellular and molecular responses of dental-derived stem cells exposed to decellularized extracellular matrix scaffolds in experimental Methods: A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science to identify relevant Results: Across the included studies, dECM scaffolds were generally associated with favorable cellular responses, including improved cell attachment, survival, and proliferation. Molecular analyses frequently reported increased expression of markers related to odontogenic and osteogenic differentiation, extracellular matrix remodeling, and cell-matrix interactions. However, the magnitude and consistency of these responses varied according to the dECM source and decellularization methodology. The majority of the studies demonstrated a medium risk of bias, reflecting limitations in methodological reporting and experimental design. Conclusion: The current Systematic Review Registration: https://doi.org/10.17605/OSF.IO/Z25HR, identifier Z25HR.
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