Evidence map›Paper›PMID 41867634›Full record

ArticleNature catalysis2026

Enantioselective Difluoromethylation of Unactivated Alkyl Halides via a Formal Nickel(II/IV) Cycle.

Xian Zhao, Lingfeng Yin, Chia-Jung Yang, Andrew T Poore, Xinyu Zhang, Stephen C Yachuw, Chao Wang, Xiao Wang, Hairong Guan, Jeanette A Krause and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xian ZhaoDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Lingfeng YinDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Chia-Jung YangDepartment of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
Andrew T PooreDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Xinyu ZhangDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Stephen C YachuwDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Chao WangDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Xiao WangDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Hairong GuanDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Jeanette A KrauseDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Mu-Jeng ChengDepartment of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
Shiliang TianDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Wei LiuDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States.

Funding

New Strategies for Copper-Catalyzed Cross-Coupling of Alkyl ElectrophilesR35GM146765 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Wei Liu · 2022 to 2026
$2.0M
Deciphering the Structures and Mechanisms of Metalloproteins Involved in Human Iron HomeostasisR35GM155016 · NIGMS · PURDUE UNIVERSITY · PI Shiliang Tian · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM146765NIGMS NIH HHS R35 GM155016
6 · The paper itself

Abstract

Nickel-catalysed enantioconvergent cross-coupling has emerged as a key strategy for constructing stereochemically defined C(sp

Identifiers

PMID41867634
PMCPMC13002026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.