Evidence map›Paper›PMID 41867623›Full record

ArticleiScience2026

Dual mechanisms of supporting cell regeneration in the neonatal mouse cochlea.

Julia M Abitbol, Maggie S Matern, Sara E Billings, Jacqueline Yao, Sung-Won Choi, Tian Wang, Stefan Heller, Alan G Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia M AbitbolDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Maggie S MaternDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Sara E BillingsDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Jacqueline YaoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Sung-Won ChoiDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Tian WangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Stefan HellerDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Alan G ChengDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Funding

A CRISPR-based toolkit for investigating hair cell transcription factors in inner ear organoidsR00DC021984 · NIDCD · MERRIMACK COLLEGE · PI Maggie S. Matern · 2025 to 2026
$498k
A CRISPR-based toolkit for investigating hair cell transcription factors in inner ear organoidsK99DC021984 · NIDCD · STANFORD UNIVERSITY · PI MATERN, MAGGIE S. · 2024 to 2025
$150k
NIDCD NIH HHS K99 DC021984NIDCD NIH HHS R00 DC021984
6 · The paper itself

Abstract

Cochlear supporting cells are glia-like cells critical for development, homeostasis, and regeneration. In the neonatal mouse cochlea, inner phalangeal cells (IPhCs), a supporting cell subtype surrounding inner hair cells, are uniquely regenerated by greater epithelial ridge (GER) cells. Here, we used fate-mapping and single-cell transcriptomic analysis to show that GER cells both mitotically and non-mitotically regenerate IPhCs. Mechanisms of regeneration are spatially distinct, with non-mitotic regeneration found throughout the cochlear spiral and mitotic regeneration restricted to the apical and middle turns. By profiling the regenerating cochlea at four time points, we revealed a damage-induced loss of medial-to-lateral specialization of GER cells. Moreover,

Indexed as

otorhinolaryngologystem cells researchtranscriptomics

Identifiers

PMID41867623
PMCPMC13000480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.