Evidence map›Paper›PMID 41867564›Full record

ArticleACS omega2026

Balancing Strength and Cell Viability in Gelatin Methacrylate/Gellan Gum Bioink Formulations.

Eduardo H Backes, Leonardo A Pinto, João F Gomes Neto, Tainara P Lima Lima, Pedro L Granja, Luiz A Pessan, Marimélia A Porcionatto

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eduardo H BackesFederal University of São Carlos (UFSCar), Graduate Program in Materials Science and Engineering (PPGCEM), São Carlos 13565-905, Brazil.ORCID https://orcid.org/0000-0003-2604-686X
Leonardo A PintoFederal University of São Carlos (UFSCar), Graduate Program in Materials Science and Engineering (PPGCEM), São Carlos 13565-905, Brazil.ORCID https://orcid.org/0000-0002-0371-7424
João F Gomes NetoFederal University of São Carlos (UFSCar), Graduate Program in Materials Science and Engineering (PPGCEM), São Carlos 13565-905, Brazil.ORCID https://orcid.org/0000-0002-0327-4846
Tainara P Lima LimaFederal University of São Carlos (UFSCar), Graduate Program in Materials Science and Engineering (PPGCEM), São Carlos 13565-905, Brazil.
Pedro L GranjaInstituto de Investigação E Inovação Em Saúde (i3S), i3S - Universidade Do Porto/Biofabrication Group, Porto 4200-135, Portugal.ORCID https://orcid.org/0000-0003-2761-4929
Luiz A PessanFederal University of São Carlos (UFSCar), Graduate Program in Materials Science and Engineering (PPGCEM), São Carlos 13565-905, Brazil.
Marimélia A PorcionattoUniversidade Federal de São Paulo (UNIFESP), Laboratory of Molecular Neurobiology, Escola Paulista de Medicina, São Paulo 04023-062, Brazil.ORCID https://orcid.org/0000-0001-6287-916X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soft tissue injuries resulting from trauma or degeneration are challenging to treat due to limited regenerative capacity, particularly in complex tissues, such as the central nervous system (CNS), nerves, and cartilage, where biomechanical and biochemical factors hinder effective repair. In these cases, tissue engineering presents a promising approach by combining biomaterials, cells, and bioactive signals to enhance soft tissue regeneration; however, its success relies on the compatibility between implanted materials and native tissue. Among the advances in this field, 3D bioprinting enables precise spatial control of the scaffold architecture and cell positioning, making it well-suited for developing constructs that mimic native tissue. In this study, we developed and characterized a series of bioink formulations based on a dual network system of gelatin methacrylate (GelMA) combined with gellan gum (GG). The GelMA/GG hydrogels were evaluated using rheological and compression testing as well as biodegradation and cell viability assays, including live/dead fluorescence microscopy. Formulations containing two different concentrations of GelMA (2.5 and 4.0% w/w) and GG (0.25 and 0.50% w/w) were tested, and the rheological results showed a strong dependence of the elastic component (

Identifiers

PMID41867564
PMCPMC13000567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.