ArticleACS omega2026
Semi-Interpenetrated Polymeric Networks of Chitosan and Poly(γ-Glutamic Acid) with Potential Biomedical Applications.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Hydrogels are polymeric matrices very similar to living tissue due to their elasticity, porosity, and ability to absorb high water content. They are highly attractive materials for a wide range of biomedical applications, such as tissue engineering, wound healing, and drug delivery. In this regard, hydrogels of semi-interpenetrating polymer networks (semi-IPNs) based on the biopolymers chitosan and poly-(γ-glutamic acid) (γ-PGA) were prepared as systems with improved properties compared to hydrogels of individual polymers. The resulting hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), porosity testing, compressive strength, cell viability, and swelling capacity. FTIR spectra of the semi-IPNs confirmed the presence of the functional groups of each polymer. SEM images revealed a porous structure of the hydrogels, which became denser and more compact with increasing γ-PGA content. This behavior was corroborated by the porosity test, which decreased with the formation of the γ-PGA-reinforced network. The swelling capacity study of the hydrogels demonstrated their sensitivity to pH and temperature. For the semi-IPN hydrogels, SF1 had the highest swelling ratio (20.55) at pH 3.6 and
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Registered trials
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