Evidence map›Paper›PMID 41867485›Full record

ArticleOptica2026

Longitudinal, label-free, high-resolution imaging of glioblastoma spheroid response to therapy: a translational tool for preclinical evaluation of chemotherapy, radiation, and immunotherapy.

Caroline E Serafini, Amin Davarzani, Dan Cappabianca, Zhenmin Li, Daniela Baez Collazos, Deniz Mamaghani, Leidong Mao, Krishanu Saha, Lohitash Karumbaiah, Francisco E Robles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Optica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline E SerafiniGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive NW, Atlanta, Georgia 30318, USA.ORCID 0000-0002-6512-5977
Amin DavarzaniRegenerative Bioscience Center, University of Georgia, 425 River Road, Athens, Georgia 30602, USA.ORCID 0000-0002-3327-5997
Dan CappabiancaDepartment of Biomedical Engineering, University of Wisconsin Madison, 330 N. Orchard Street, Madison, Wisconsin 53715, USA.
Zhenmin LiSchool of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, Georgia 30332, USA.
Daniela Baez CollazosThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, Georgia 30332, USA.
Deniz MamaghaniRegenerative Bioscience Center, University of Georgia, 425 River Road, Athens, Georgia 30602, USA.
Leidong MaoRegenerative Bioscience Center, University of Georgia, 425 River Road, Athens, Georgia 30602, USA.
Krishanu SahaDepartment of Biomedical Engineering, University of Wisconsin Madison, 330 N. Orchard Street, Madison, Wisconsin 53715, USA.
Lohitash KarumbaiahRegenerative Bioscience Center, University of Georgia, 425 River Road, Athens, Georgia 30602, USA.
Francisco E RoblesGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive NW, Atlanta, Georgia 30318, USA.ORCID 0000-0003-4413-9779

Funding

Accessible label-free optical microscopy with quantitative molecular and functional contrastR35GM147437 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Francisco E Robles · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147437
6 · The paper itself

Abstract

Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options and poor patient survival, underscoring the need for novel, to our knowledge, therapeutic strategies and improved preclinical models. Patient-derived tumor spheroids (PDTSs) offer a physiologically relevant

Identifiers

PMID41867485
PMCPMC13003926

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.