ArticleJournal of inflammation research2026
Systemic Inflammation Mediates the Association Between Atrial Fibrillation and Functional Outcomes After Ischemic Stroke.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Atrial fibrillation (AF) is a major risk factor for ischemic stroke and is associated with worse neurological outcomes. The mechanisms underlying this relationship, particularly the role of systemic inflammation as a mediator linking AF to post-stroke functional outcomes, remain insufficiently understood. Methods: We conducted a retrospective cohort study of 463 patients with acute ischemic stroke (median age 67.0 years [IQR 56.0-74.0]; 27.0% female), including 96 with AF. Candidate mediators were identified using least absolute shrinkage and selection operator (LASSO) regression and single-mediator causal mediation models were applied adjusting for established confounders. Robustness was evaluated using E-values. Results: Patients with AF had more severe neurological deficits and had poorer 90-day functional outcomes. The multivariable model incorporating LASSO-selected variables demonstrated better predictive performance (AUC 0.829) compared to a confounder-only model (AUC 0.757). Mediation analysis demonstrated that neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation response index (SIRI) significantly mediated 22.3% and 17.0% of the association between AF and poor functional outcome, suggesting that systemic inflammation contributes meaningfully to AF-related post-stroke disability. Conclusion: NLR and SIRI partially mediate the association between AF and poor functional outcomes after ischemic stroke, suggesting that systemic inflammation may serve as a potential prognostic marker and that these indices could aid early risk stratification.
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